Keywords: هدف مواد مخدر; Leishmania donovani; Metabolic pathway; Drug target; Protein;
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Keywords: هدف مواد مخدر; Chemical proteomics; Curcumol; NCL; Drug target; Nasopharyngeal carcinoma;
Keywords: هدف مواد مخدر; Malaria; Plasmodium; Toxoplasma gondii; Lipid; Phosphoinositide; Drug target; Lipid kinase; Lipid phosphatase;
Keywords: هدف مواد مخدر; Adenosine; Adenosine receptor; Drug target; Drug discovery; Pharmacology; Disease; T1D; type 1 diabetes; T2D; type 2 diabetes; A1AR; A1 adenosine receptor; A2AAR; A2A adenosine receptor; A2BAR; A2B adenosine receptor; A3AR; A3 adenosine receptor;
Keywords: هدف مواد مخدر; High-throughput screening; Drug target; Drug interactions; Genomics; Drug resistance;
Keywords: هدف مواد مخدر; Cryptosporidiosis; Calcium-dependent protein kinase 1; Gatekeeper residue; Drug target; BKI 1369;
Keywords: هدف مواد مخدر; Tuberculosis; Mycobacterium tuberculosis; Resistance; Drug target; Mechanism;
Keywords: هدف مواد مخدر; Dihydroorotate dehydrogenase; Flavoenzyme; Pyrimidine biosynthesis; Drug target;
Keywords: هدف مواد مخدر; OC, ovarian cancer; HSP, heat shock proteins; 17-AAG, 17-allylamino-demethoxygeldanamycinOvarian cancer; Heat shock protein; Diagnosis; Drug target; Chemoresistance
Keywords: هدف مواد مخدر; Ikaros family; Zinc-finger; Lymphocyte development; Drug target; Transcription factor;
Keywords: هدف مواد مخدر; Sarcocystis neurona; Equine protozoal myeloencephalitis; Calcium-dependent protein kinase 1; Gatekeeper residue; Drug target; Bumped kinase inhibitors;
Keywords: هدف مواد مخدر; Malaria; Plasmodium falciparum; Pyrimidine biosynthetic pathway; Drug target; Drug development; Chemotherapy
Keywords: هدف مواد مخدر; Leishmaniasis; Mechanism of Action; Drug discovery; Drug target; Phenotypic assay
Keywords: هدف مواد مخدر; Angiogenesis; Cancer; Drug target; Pleiotrophin; Receptor protein tyrosine phosphatase zeta; Therapy;
Keywords: هدف مواد مخدر; Neurodegenerative diseases; Cell toxicity; Drug target; Therapeutic intervention; Misfolding and aggregation;
Keywords: هدف مواد مخدر; ADHD; attention deficit/hyperactivity disorder; ASD; autism spectrum disorder; BDNF; brain-derived neurotrophic factor; CHL1; cell adhesion molecule L1-like; DT; drug target; GABA; gamma-aminobutyric acid; GWAS; genome-wide association studies; GRIK4; ion
Keywords: هدف مواد مخدر; Bioinformatics; Drug target; Heavy path mining; Genomics; Malaria; Systems biology
Keywords: هدف مواد مخدر; Influenza; Nucleoprotein; Molecular evolution; Drug target; Sequence conservation;
Keywords: هدف مواد مخدر; Genome sequencing; Genome structure; Antigenic variation; Comparative genomics; Drug target;
Keywords: هدف مواد مخدر; Baicalin; Candida albicans; Drug target; Apoptosis;
Keywords: هدف مواد مخدر; Machine learning; Drug target; SVM;
Keywords: هدف مواد مخدر; ClpP; AAA+ chaperones/Clp-ATPases; Drug target; Virulence target; Acyldepsipeptide antibiotics (ADEPs); Beta-lactones
Keywords: هدف مواد مخدر; Heparanase; Heparanase inhibitors; Drug target; Antitumor therapy
Keywords: هدف مواد مخدر; Zinc-binding; Geometric restriction; Training-independent; Cancer gene; Drug target
Keywords: هدف مواد مخدر; Solute carrier; SLC; Clinical trials; SSRI; Drug target;
Keywords: هدف مواد مخدر; BOE; Boletin Oficial del Estado (Spanish Official Press bulletin); BRITE; biomolecular relations in information transmission and expression; CE; European Commission; emPAI; exponentially modified protein abundance index; ES; excretory-secretory; FABP; f
Keywords: هدف مواد مخدر; ADME; absorption, distribution, metabolism and excretion; ADMET; absorption, distribution, metabolism, excretion and toxicity; FDA; USA Food and Drug Administration; GWAS; genome-wide association study; mTOR; mammalian target of rapamycin; NME; new molecu
Depletion of the extracellular-signal regulated kinase 8 homolog in Trypanosoma brucei in vivo reduces its virulence in a mouse target validation study
Keywords: هدف مواد مخدر; Trypanosoma brucei; in vivo; MAPK; Drug target; DNA; replicationReplication; RNAi;
eIF3a: A new anticancer drug target in the eIF family
Keywords: هدف مواد مخدر; Anticancer; Drug target; eIF3a; Translation initiation; Translation regulation;
Lipoic acid metabolism in Trypanosoma cruzi as putative target for chemotherapy
Keywords: هدف مواد مخدر; Lipoic acid; Protein lipoylation; Drug target; Chagas disease; Trypanosoma;
TFCP2/TFCP2L1/UBP1 transcription factors in cancer
Keywords: هدف مواد مخدر; Drug target; Hepatocellular carcinoma; Oncogene; Stem cells; Grainyhead;
Babesia microti thioredoxin 3 is an effective antioxidant and involved in the response to antiprotozoal drugs
Keywords: هدف مواد مخدر; Trx; thioredoxin; TrxR; thioredoxin reductase; NADPH; nicotinamide adenine dinucleotide phosphate; BmTrx3; B. microti thioredoxin 3; RACE; rapid amplification of cDNA ends; IFA; Immunofluorescence assay; IPTG; Isopropyl β-d-1-Thiogalactopyranoside; PBS;
Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients
Keywords: هدف مواد مخدر; mTORC1; Stat3; Inflammation; Drug target; Psychiatric disorders; Microglia; Phosphoflow;
Modelling studies determing the mode of action of anthelmintics inhibiting in vitro trehalose-6-phosphate phosphatase (TPP) of Anisakis simplex s.l
Keywords: هدف مواد مخدر; TPP; Anisakis simplex; Drug target; Docking studies; Ivermectin; Levamisole;
Structural modeling identifies Plasmodium vivax 4-diphosphocytidyl-2C-methyl-d-erythritol kinase (IspE) as a plausible new antimalarial drug target
Keywords: هدف مواد مخدر; Plasmodium vivax; Methylerythritol phosphate (MEP) pathway; 4-Diphosphocytidyl-2C-methyl-d-erythritol kinase (IspE) gene; Genetic diversity; Phylogenetic analysis; Molecular modeling; Antimalarial; Drug target;
TNK2 as a key drug target for the treatment of metastatic colorectal cancer
Keywords: هدف مواد مخدر; Colorectal cancer; Drug target; Small molecular compound; Bioinformatics;
The conserved hypothetical protein Tb427.10.13790 is required for cytokinesis in Trypanosoma brucei
Keywords: هدف مواد مخدر; DAPI; 4´, 6-diamidino-2-phenylindole; DIC; differential interference contrast; dsRNA; double-stranded RNA; eGFP; enhanced green fluorescent protein; FAZ; flagellum attachment zone; HAT; human African trypanosomiasis; ORF; open reading frame; qRT-PCR; qua
The 3â²-end region of the human PDGFR-β core promoter nuclease hypersensitive element forms a mixture of two unique end-insertion G-quadruplexes
Keywords: هدف مواد مخدر; G-quadruplex; End-insertion G-quadruplexes; PDGFR-β gene downregulation; Drug target;
Ganglioside GD3 synthase (GD3S), a novel cancer drug target
Keywords: هدف مواد مخدر; Ganglioside; GD3; GD2; GD3S; Drug target; Cancer treatment;
Biochemical characterization of unusual cysteine protease of P. falciparum, metacaspase-2 (MCA-2)
Keywords: هدف مواد مخدر; Malaria; Proteases; Drug target; Metacaspase-2; Z-FA-FMK; Tudor staphylococcal nuclease; Apoptosis;
Rough set method accurately predicts unknown protein class/family of Leishmania donovani membrane proteome
Keywords: هدف مواد مخدر; Leishmania donovani; Rough set method; Protein class/family; Drug target; Therapy;
Pyridoxal kinase: A vitamin B6 salvage pathway enzyme from Leishmania donovani
Keywords: هدف مواد مخدر; Leishmania; Pyridoxal kinase; Drug target;
Exploring molecular insights into the interaction mechanism of cholesterol derivatives with the Mce4A: A combined spectroscopic and molecular dynamic simulation studies
Keywords: هدف مواد مخدر; Mycobacterium tuberculosis; Mce4A; Molecular docking; Drug target; Molecular dynamics simulation;
The G protein-coupled receptors deorphanization landscape
Keywords: هدف مواد مخدر; GPCRs; G protein-coupled receptors; GRK; GPCR kinase; IUPHAR; International Union of Basic and Clinical Pharmacology; BPS; British Pharmacological Society; CTR; Calcitonin receptor; CLR; CT Receptor-like; RAMP; Receptor Activity-Modifying Proteins; β2AR;
Members of FOX family could be drug targets of cancers
Keywords: هدف مواد مخدر; FOX; Forkhead box; BLBC; basal-like breast cancer; HCC; Hepatocellular carcinoma; NSCLC; Non-small-cell lung cancer; ALL; Acute lymphoblastic leukemia; CRC; Colorectal cancer; TNBC; Triple negative breast cancer; CSC; Cancer stem cell; ESC; Embryonic stem
Highlights for the 6th International Ion Channel Conference: ion channel structure, function, disease and therapeutics
Keywords: هدف مواد مخدر; Ion channel; Structure; Function; Channelopathy; Drug target; Mechanotransduction; Voltage-gated Ca2+ channel; Anoctamin-1; Calcium activated chloride channel; M-type potassium channel; GIRK channel; Voltage-gated sodium channel;
Using reverse docking to identify potential targets for ginsenosides
Keywords: هدف مواد مخدر; drug target; ginsenoside; ligand screening; protein docking; reverse docking;
RNA as a small molecule druggable target
Keywords: هدف مواد مخدر; Non-coding RNA; ncRNA; Drug target; Small molecule; Target validation; Functional;
Research paperNovel peptide MT23 for potent penetrating and selective targeting in mouse melanoma cancer cells
Keywords: هدف مواد مخدر; Cell penetrating peptide; Drug target; Melanoma cancer cell;
Research ArticleInsights into structure and function of 30S Ribosomal Protein S2 (30S2) in Chlamydophila pneumoniae: A potent target of pneumonia
Keywords: هدف مواد مخدر; Chlamydophila pneumoniae; 30S ribosomal protein S2; Pneumonia; Drug target; Structure; Function; Ramachandran plot; Profunc server;