دانلود مقالات ISI درباره هدف مواد مخدر + ترجمه فارسی

Negative symptoms and psychosocial functioning in schizophrenia: Neglected but important targets for treatment

Keywords: هدف مواد مخدر; Schizophrenia; Negative symptoms; Psychosocial function; Drug target

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Frizzled7 as an emerging target for cancer therapy

Keywords: هدف مواد مخدر; ALL; Acute lymphoblastic leukemia; APC; Adenomatous polyposis coli; CamKII; Calmodulin kinase II; Cthrc1; Collagen triple helix repeat containing protein; CK1; Caseine kinase 1; CTNNB1; β-catenin gene; CRD; Cysteine rich domain; CSC; Cancer stem cells; D

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Identification and characterization of a novel Ribose 5-phosphate isomerase B from Leishmania donovani

Keywords: هدف مواد مخدر; Leishmaniasis; Leishmania donovani; Drug target; Pentose phosphate pathway (PPP); Ribose 5-phosphate isomerase (Rpi); Ribose 5-phosphate isomerase B (RpiB);

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Target-based and whole-worm screening approaches to anthelmintic discovery

Keywords: هدف مواد مخدر; Nematode; Bacillus; Cuticle; Ecdysone; Drug target

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips

Keywords: هدف مواد مخدر; PDMS microfluidic biochip; Kidney; Ifosfamide; Inflammation; Cancer; Transcriptomic; Drug target

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Evaluation of CoA biosynthesis proteins of Mycobacterium tuberculosis as potential drug targets

Keywords: هدف مواد مخدر; Coenzyme A biosynthesis; Essentiality; Drug target; Knockout; Homology;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

The crystal structure of Leishmania major N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target

Keywords: هدف مواد مخدر; Antifolate; Cyclohydrolase; Dehydrogenase; Drug target; Leishmania; Trypanosoma;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

The trypanothione system and the opportunities it offers to create drugs for the neglected kinetoplast diseases

Keywords: هدف مواد مخدر; Antioxidant defense; DNA synthesis; Drugability; Drug target; Leishmaniasis; Target validation; Trypanosomiasis; Trypanothione; Trypanothione synthetase; Tryparedoxin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

A plasma membrane Ca2+-ATPase (PMCA) from the liver fluke, Fasciola hepatica

Keywords: هدف مواد مخدر; Fasciola hepatica; P-type ATPase; ATP-dependent membrane transport protein; Calmodulin; Drug target; Yeast model

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Trypanosoma brucei: Chemical evidence that cathepsin L is essential for survival and a relevant drug target

Keywords: هدف مواد مخدر; Trypanosomiasis; Cysteine peptidase; Protease inhibitor; Drug target

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

RNAi mediated silencing of ATPase RNA helicase gene in adult filarial parasite Brugia malayi impairs in vitro microfilaria release and adult parasite viability

Keywords: هدف مواد مخدر; RNAi; Filaria; Drug target; B. malayi; RNA helicase; Embryogenesis

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

In silico prediction of antimalarial drug target candidates

Keywords: هدف مواد مخدر; Plasmodium falciparum; Phylogenomics; Gene essentiality; Drug target

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Minireview: The role of the vacuolar ATPase in nematodes

Keywords: هدف مواد مخدر; Vacuolar ATPase; Nematode; Drug target; Caenorhabditis elegans; Osmoregulation; Reproduction;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of common human host genes involved in pathogenesis of different rotavirus strains: An attempt to recognize probable antiviral targets

Keywords: هدف مواد مخدر; Rotavirus strain; Host gene expression regulation; Microarray; Drug target; USP18; A20;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of potential drug targets in Yersinia pestis using metabolic pathway analysis: MurE ligase as a case study

Keywords: هدف مواد مخدر; Docking; Drug target; Metabolic pathways; MurE ligase; Plague; Yersinia pestis;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2

Keywords: هدف مواد مخدر; ACP; acyl carrier protein; GDH; glutamate dehydrogenase; ROS; reactive oxygen species; GW5074; 3-(3,5-dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one; TCA; tricarboxylic acid; G6PDH; glucose-6-phosphate dehydrogenase; Tricarboxylic acid metabol

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Protein target discovery of drug and its reactive intermediate metabolite by using proteomic strategy

Keywords: هدف مواد مخدر; Drug target; Reactive metabolite; Proteomics; Mass spectrometry

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

The kinomes of apicomplexan parasites

Keywords: هدف مواد مخدر; Apicomplexa; Kinase inhibitor; Hidden Markov model; Protein classification; Drug target; Kinome; PK; protein kinase; ePK; conventional PK; aPK; atypical PK; OPK; 'Other' PK; HMM; profile hidden Markov model;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: Focus on pharmacology and preclinical translational models

Keywords: هدف مواد مخدر; Animal model; Anxiety disorder; Anxiolytic; Posttraumatic stress disorder; Obsessive-compulsive disorder; GABA; Glutamate; Nitric oxide; Ionotropic; Metabotropic; Translational; Drug target;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2012 سفارش ترجمه

Stearoyl-CoA desaturase is an essential enzyme for the parasitic protist Trypanosoma brucei

Keywords: هدف مواد مخدر; Fatty-acid desaturase; Drug target; Trypanosoma brucei; Thiastearic acid; Isoxyl; RNA interference;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8

Keywords: هدف مواد مخدر; Metalloenzyme; Enzyme inhibitor; Drug target

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Targeting AMPK for cardiac protection: Opportunities and challenges

Keywords: هدف مواد مخدر; AMPK; Energy homeostasis; Drug target; Isoform; Cardiomyopathy

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs

Keywords: هدف مواد مخدر; Toxoplasma; Neospora; Host cell; Drug target; Quinone reductase; Thiazolides;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Identification and characterization of the cofactor-independent phosphoglycerate mutases of Dirofilaria immitis and its Wolbachia endosymbiont

Keywords: هدف مواد مخدر; Cofactor-independent phosphoglycerate mutase; Drug target; Dirofilaria immitis; Wolbachia; Chemotherapy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2

Keywords: هدف مواد مخدر; Protein kinase CK2; Drug target; Inhibitor; Thienopyrimidine; Docking; Organic synthesis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico

Keywords: هدف مواد مخدر; Plasmodium; Drug target; Metabolic network; Chokepoints

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico

Keywords: هدف مواد مخدر; Plasmodium; Drug target; Metabolic network; Chokepoints

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

MMAR_2770, a new enzyme involved in biotin biosynthesis, is essential for the growth of Mycobacterium marinum in macrophages and zebrafish

Keywords: هدف مواد مخدر; Mycobacterium marinum; Biotin biosynthesis; Drug target;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Cloning, expression, purification and kinetics of trehalose-6-phosphate phosphatase of filarial parasite Brugia malayi

Keywords: هدف مواد مخدر; Brugia malayi; Trehalose-6-phosphate phosphatase; Drug target; Antifilarial; Lymphatic filariasis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Malaria parasite carbonic anhydrase: inhibition of aromatic/heterocyclic sulfonamides and its therapeutic potential

Keywords: هدف مواد مخدر; Malaria; Plasmodium falciparum; Carbonic anhydrase; Carbonic anhydrase inhibitor; Aromatic/heterocyclic sulfonamides; Antimalarial agents; Drug target; Biological medicine; Tropical disease; Infectious disease; Parasitic disease;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Structural basis for pH dependent monomer–dimer transition of 3,4-dihydroxy 2-butanone-4-phosphate synthase domain from Mycobacterium tuberculosis

Keywords: هدف مواد مخدر; Riboflavin; FMN/FAD; Antibacterial; Drug target; VitaminB2

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster

Keywords: هدف مواد مخدر; Signaling pathways; Wnt; Hedgehog; Cancer; Drug target;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Experimental determination and prediction of bilitranslocase transport activity

Keywords: هدف مواد مخدر; Drug target; Bilitranslocase transport activity; Inhibition constants; Classification; Predictive models; Artificial neural network; Variable selection; Applicability domain

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate

Keywords: هدف مواد مخدر; Aminoacyl-tRNA synthetase; Protozoa; Drug target; Leishmaniasis; Trypanosomiasis; Enzyme product complex; aaRS; aminoacyl-tRNA synthetase; AQP; adenosine-5′-tetraphosphate; CP1; connective peptide insertion 1; CP2; connective peptide insertion 2; AspRS;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Human group III PLA2 as a drug target: Structural analysis and inhibitor binding studies

Keywords: هدف مواد مخدر; Human group III phospholipase A2; Drug target; Ligand binding

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Analysis of adverse drug reactions using drug and drug target interactions and graph-based methods

Keywords: هدف مواد مخدر; Adverse drug reaction; Drug target; Drug target ontology; Clustering coefficient; Drug–drug interaction

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells

Keywords: هدف مواد مخدر; Apoptosis signal-regulating kinase; ASK1; ASK3; MAP3K15; Cell death; Drug target

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Combination of DEC plus aspirin induced mitochondrial mediated apoptosis in filarial parasite Setaria cervi

Keywords: هدف مواد مخدر; Filariasis; Diethylcarbamazine; Aspirin; Apoptosis; Drug target

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

X-ray structures of NS1 effector domain mutants

Keywords: هدف مواد مخدر; NS1 effector domain; Influenza protein; Drug target; Protein engineering

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90α/β

Keywords: هدف مواد مخدر; RAD, radicicol; GdA, geldanamycin; 17-AAG, 17-allylamino-demethoxygeldanamycin; DMSO, dimethylsulphoxide; 5-FOA, 5-fluoroorotic acidHsp90; Molecular chaperone; Cancer; Drug target; Drug resistance; Yeast

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

A survey of yeast genomic assays for drug and target discovery

Keywords: هدف مواد مخدر; Yeast; Chemical genomics; Chemical biology; Drug target; Drug actionYKO, Yeast KnockOut collection; HIP, HaploInsufficiency Profiling; MSP, Multi-copy suppression profiling; SGA, Synthetic genetic array; ORF, Open reading frame; MoBY-ORF, Molecular-barcod

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

LmxMPK4, an essential mitogen-activated protein kinase of Leishmania mexicana is phosphorylated and activated by the STE7-like protein kinase LmxMKK5

Keywords: هدف مواد مخدر; Leishmania mexicana; Mitogen-activated protein kinase; Drug target; MAP2K; Co-expression

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism

Keywords: هدف مواد مخدر; Pentose phosphate pathway; Drug target; Bacterial adhesin; Synchrotron; Crystallography

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Malignant pleural mesothelioma: Genome-wide expression patterns reflecting general resistance mechanisms and a proposal of novel targets

Keywords: هدف مواد مخدر; Chemo-resistance; DNA repair; Drug target; Fanconi anemia; Homologous recombination; Microarray; Radiation resistance

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

A comparison of machine learning techniques for detection of drug target articles

Keywords: هدف مواد مخدر; Biomedical text classification; Biomedical information retrieval; Drug discovery; Drug target; Machine learning; Support Vector Machines; Naïve Bayes; Unified Medical Language System; MetaMap

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Plasmodium falciparum: Organelle-specific acquisition of lipoic acid

Keywords: هدف مواد مخدر; ACP; acyl carrier protein; DHLA; dihydrolipoic acid; GCS; glycine cleavage system; KADH; α-keto acid dehdyrogenase complex; LA; lipoic acid; PDH; pyruvate dehydrogenase; PVM; parasitophorous vacuolar membrane; Malaria; Drug target; Apicoplast; Mitochondr

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Genomics: Applications in mechanism elucidation

Keywords: هدف مواد مخدر; Mechanism of action; Drug discovery; Genomics; Drug target; Small molecule drugs; Molecular interactions; Pharmacogenomics

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

The FIP-1 like polyadenylation factor in trypanosomes and the structural basis for its interaction with CPSF30

Keywords: هدف مواد مخدر; Y2H; yeast two-hybrid; ONPG; ortho-nitrophenyl-β-galactoside; SOEing PCR; splice overlap extension PCR; CPSF; cleavage and polyadenylation specificity factor; FIP; Factor Interacting with PAP; Polyadenylation factors; mRNA processing; Protein interaction

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Probing the roles of non-homologous insertions in the N-terminal domain of Plasmodium falciparum hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase

Keywords: هدف مواد مخدر; DHFR; dihydrofolate reductase; DHFS; dihydrofolate synthetase; DHPS; dihydropteroate synthase; HPPK; hydroxymethylpterin pyrophosphokinase; TS; thymidylate synthase; HMP; 6-hydroxymethylpterin; HMDP; 6-hydroxymethyl-7,8-dihydropterin; HMDPP; 6-hydroxymeth

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Steady-state kinetics of indole-3-glycerol phosphate synthase from Mycobacterium tuberculosis

Keywords: هدف مواد مخدر; Tuberculosis; Drug target; Indole-3-glycerol phosphate synthase; 1-(o-Carboxyphenylamino)-1-deoxyribulose 5-phosphate; IGPS; Steady-state kinetics

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه