کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10231908 | 1395 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
- The newly reconstructed Wnt/β-catenin signaling network in Drosophila melanogaster consists of 656 proteins and 1253 interactions whereas Hedgehog signaling network consists of 523 proteins and 945 interactions among these proteins. Both networks have small-world and scale-free topology, they possess the general characteristic of complex biological networks.
- According to the results of structural network analyses, the proteins Arm, Frizzled receptors (Fz and Fz2), Arr, Apc, Axn, Ci and Ptc were detected as the key proteins in these networks. The hub protein Mer having tumor suppressor function may be proposed as a putative drug target for cancer and deserves further investigation via experimental methods.
- Crosstalk analysis revealed that 477 proteins are common between the reconstructed Wnt/β-catenin and Hedgehog networks and it can be concluded that these two signaling networks crosstalk to each other.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Biology and Chemistry - Volume 35, Issue 5, 12 October 2011, Pages 282-292
Journal: Computational Biology and Chemistry - Volume 35, Issue 5, 12 October 2011, Pages 282-292
نویسندگان
Aysun Eren Toku, Saliha DurmuÅ Tekir, Fatma Betül Kavun Ãzbayraktar, Kutlu Ã. Ãlgen,