Minireview: The role of the vacuolar ATPase in nematodes

► The V-ATPase is an enzyme complex with diverse cellular roles. ► Nematode V-ATPases are involved in many essential processes. ► Three key processes are osmoregulation, cuticle secretion and nutrient absorption. ► The nematode V-ATPase could provide a nematode drug target. ► Libraries of V-ATPase inhibitors exist; they should be screened in nematodes.