کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
378064 658872 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of adverse drug reactions using drug and drug target interactions and graph-based methods
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر هوش مصنوعی
پیش نمایش صفحه اول مقاله
Analysis of adverse drug reactions using drug and drug target interactions and graph-based methods
چکیده انگلیسی

ObjectiveThe purpose of this study was to integrate knowledge about drugs, drug targets, and topological methods. The goals were to build a system facilitating the study of adverse drug events, to make it easier to find possible explanations, and to group similar drug–drug interaction cases in the adverse drug reaction reports from the US Food and Drug Administration (FDA).MethodsWe developed a system that analyses adverse drug reaction (ADR) cases reported by the FDA. The system contains four modules. First, we integrate drug and drug target databases that provide information related to adverse drug reactions. Second, we classify drug and drug targets according to anatomical therapeutic chemical classification (ATC) and drug target ontology (DTO). Third, we build drug target networks based on drug and drug target databases. Finally, we apply topological analysis to reveal drug interaction complexity for each ADR case reported by the FDA.ResultsWe picked 1952 ADR cases from the years 2005–2006. Our dataset consisted of 1952 cases, of which 1471 cases involved ADR targets, 845 cases involved absorption, distribution, metabolism, and excretion (ADME) targets, and 507 cases involved some drugs acting on the same targets, namely, common targets (CTs). We then investigated the cases involving ADR targets, ADME targets, and CTs using the ATC system and DTO. In the cases that led to death, the average number of common targets (NCTs) was 0.879 and the average of average clustering coefficient (ACC) was 0.067. In cases that did not lead to death, the average NCTs was 0.551, and the average of ACC was 0.039.ConclusionsWe implemented a system that can find possible explanations and cluster similar ADR cases reported by the FDA. We found that the average of ACC and the average NCTs in cases leading to death are higher than in cases not leading to death, suggesting that the interactions in cases leading to death are generally more complicated than in cases not leading to death. This indicates that our system can help not only in analysing ADRs in terms of drug–drug interactions but also by providing drug target assessments early in the drug discovery process.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Artificial Intelligence in Medicine - Volume 48, Issues 2–3, February–March 2010, Pages 161–166
نویسندگان
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