The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target
Keywords: هدف مواد مخدر; Trypanosoma; Trypanosomiasis; Sphingolipid synthase; Drug target;
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Drug targets for tumorigenesis: Insights from structural analysis of EGFR signaling network
Keywords: هدف مواد مخدر; Signal transduction; Epidermal growth factor receptor; Graph theory; Network decomposition analysis; Tumorigenesis; Drug target
A histidine kinase PmHHK1 regulates polar growth, sporulation and cell wall composition in the dimorphic fungus Penicillium marneffei
Keywords: هدف مواد مخدر; Cell wall; Drug target; Histidine kinase; Polar growth; Promoter; RNA interference; Sporulation; dsRNAi; double-strand RNA interference; HK; histidine kinase; RR; response regulator; P. marneffei; Penicillium marneffei;
Targeting the WNT/β-catenin/TCF/LEF1 axis in solid and haematological cancers: Multiplicity of therapeutic options
Keywords: هدف مواد مخدر; Drug target; β-Catenin; T-cell factor (TCF); Lymphoid enhancer factor 1 (LEF1); WNT signalling
The cytosolic tryparedoxin of Leishmania infantum is essential for parasite survival
Keywords: هدف مواد مخدر; Leishmania infantum; Visceral leishmaniasis; Tryparedoxin; Drug target
Chemical evaluation of fatty acid desaturases as drug targets in Trypanosoma cruzi
Keywords: هدف مواد مخدر; Fatty acids; Desaturase; Drug target; Trypanosoma cruzi; Chagas’ disease; Isoxyl; Thia fatty acid; Thiastearate
Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin
Keywords: هدف مواد مخدر; Serotonin transporter; Parasite; Drug target; SERT; Allele; Gene expression
Leishmania major CorA-like magnesium transporters play a critical role in parasite development and virulence
Keywords: هدف مواد مخدر; Leishmania major; Ion transporter; Magnesium; Knockout parasite; Virulence; Drug target
Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity
Keywords: هدف مواد مخدر; Helminth; Metabolism; Enzyme; Evolution; Adaptation; Urea; Trematode; Drug target
6-Br-5methylindirubin-3â²oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: Exploitation of GSK-3 for treating leishmaniasis
Keywords: هدف مواد مخدر; Leishmania donovani glycogen synthase kinase-3 short; 5-Me-6-BIO; 6-BIO; Indirubins; Apoptosis-like death; Drug target;
Plasmodium falciparum: Growth response to potassium channel blocking compounds
Keywords: هدف مواد مخدر; Plasmodium falciparum; Malaria; Potassium channel; Drug target
Long-term expressional changes of Na+–K+–Cl− co-transporter 1 (NKCC1) and K+–Cl− co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE)
Keywords: هدف مواد مخدر; Cation–chloride co-transporter; Gene expression; Drug target
Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis
Keywords: هدف مواد مخدر; Siderophore; Antimicrobial; Drug target; Mycobacterium tuberculosis; Yersinia pestis; Diaryl-carbothioamide-pyrazolines
Development of novel magnetic nano-carriers for high-performance affinity purification
Keywords: هدف مواد مخدر; Magnetite; Polymerization; Magnetic carrier; Affinity purification; Drug target
Novel pharmacological targets based on receptor heteromers
Keywords: هدف مواد مخدر; GPCR, G-protein-coupled receptor; KD, Dissociation constant; DC, dimer cooperativity indexAdenosine; Cannabinoid; Dopamine; Opioid; Fitting data; Receptor dimer; Receptor oligomer; Allosteric regulation; Cooperativity; Drug target
Neospora caninum: Functional inhibition of protein disulfide isomerase by the broad-spectrum anti-parasitic drug nitazoxanide and other thiazolides
Keywords: هدف مواد مخدر; Nitazoxanide; Thiazolides; Neospora caninum; Drug target; Protein disulfide isomerase
Purification and biochemical characterization of cytosolic glutathione-S-transferase from filarial worms Setaria cervi
Keywords: هدف مواد مخدر; Glutathione-S-transferase; Purification; Characterization; Drug target; Enzyme inhibition; Glutathione metabolism; Glutathione peroxidase; Filariasis; Helminth parasites; Setaria cervi;
Succinic semialdehyde dehydrogenase from the parasitic cattle tick Rhipicephalus microplus: Gene identification, biochemical characterization and comparison with the mouse ortholog
Keywords: هدف مواد مخدر; GABA catabolism; Succinic semialdehyde dehydrogenase; Ectoparasite; Enzyme kinetics; Drug target;
The apicomplexan parasite Toxoplasma gondii generates pyridoxal phosphate de novo
Keywords: هدف مواد مخدر; PLP; pyridoxal 5â² phosphate; PdxK; pyridoxine kinase; TgPdx1; T. gondii Pdx1; TgPdx2; T. gondii Pdx2; ODC; ornithine decarboxylase; Pdx1; Pdx2; Pyridoxine; Pyridoxal phosphate; Drug target; PLP;
Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk
Keywords: هدف مواد مخدر; Pfmrk; CDK7; Protein kinase A; Malaria; Plasmodium falciparum; Kinase inhibitors; Cyclin dependent protein kinase; Anti-malarials; Drug target; Parasite
141st ENMC International Workshop Inaugural Meeting of the EURO-Laminopathies Project Nuclear Envelope-linked Rare Human Diseases: From Molecular Pathophysiology towards Clinical Applications 10-12 March 2006, Naarden, The Netherlands
Keywords: هدف مواد مخدر; ENMC; European Neuromuscular Center; LAP; Lamina-associated polypeptide; pRb; retinoblastoma protein; UMD; Universal mutation database; Animal disease models; Atomic structure; Cell cycle; Chromosomes; Drug target; Lamins; Molecular disease mechanism; The
Pharmacogénomique et pharmacoprotéomique
Keywords: هدف مواد مخدر; Pharmacogénomique; Pharmacoprotéomique; Médicaments à visée cardio-vasculaire; Enzymes du métabolisme du médicament; Transporteurs ABC; Cibles thérapeutiques; Statines; Pharmacogenomics; Pharmacoproteomics; Cardiovascular drug; Drug-metabolizing e
Discovering drug targets through the web
Keywords: هدف مواد مخدر; Drug; Disease; Drug target; Bioinformatics; Sequence comparison; Text mining
Chaperoning a cellular upheaval in malaria: Heat shock proteins in Plasmodium falciparum
Keywords: هدف مواد مخدر; Chaperones; Heat shock proteins; Plasmodium; Malaria; Drug target
Pharmacological protein targets in polyglutamine diseases: Mutant polypeptides and their interactors
Keywords: هدف مواد مخدر; Neurodegeneration; Polyglutamine disease; Polypeptide; Protein conformation; Drug target;
Kinetic and chemical mechanisms of shikimate dehydrogenase from Mycobacterium tuberculosis
Keywords: هدف مواد مخدر; Shikimate dehydrogenase; Tuberculosis; Drug target; 3-Dehydroshikimate; Shikimate; Kinetic mechanism; Chemical mechanism; Mycobacterium tuberculosis;
X-Ray Crystal Structure of Mycobacterium tuberculosis β-Ketoacyl Acyl Carrier Protein Synthase II (mtKasB)
Keywords: هدف مواد مخدر; mt, Mycobacterium tuberculosis; ec, Escherichia coli; TB, tuberculosis; FAS, fatty acid synthases; TLM, thiolactomycin; ACP, acyl carrier protein; KAS, β-ketoacyl ACP synthasefatty acid biosynthesis; FAS-II; mtKasB; thiolactomycin; drug target
Current status of excision repair cross complementing-group 1 (ERCC1) in cancer
Keywords: هدف مواد مخدر; Platinating agents; Nucleotide excision repair; ERCC1; Cancer; Predictive marker; Prognostic marker; Drug target
Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms
Keywords: هدف مواد مخدر; DHOD; dihydroorotate dehydrogenase; ACT; aspartate carbamoyltransferase; pyr; de novo pyrimidine biosynthetic gene; Trypanosoma cruzi; Dihydroorotate dehydrogenase; Pyrimidine-biosynthetic gene cluster; Genetic diversity; Drug target;
Naegleria fowleri: A free-living highly pathogenic amoeba contains trypanothione/trypanothione reductase and glutathione/glutathione reductase systems
Keywords: هدف مواد مخدر; Drug target; Naegleria fowleri; Cysteine; Glutathione; Trypanothione; Glutathione reductase; Trypanothione reductase; T(S)2, trypanothione disulphide; Gspd, glutathionyl-spermidine; MALDI-TOF, matrix assisted laser-desorption ionization-time-of-flight; mB
The drug designer´s guide to selectivity
Keywords: هدف مواد مخدر; Amino acid; DLG5; Drug design; Drug target; PCA; PDZ; PLS-DA; Selectivity; Sequence alignment
Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania
Keywords: هدف مواد مخدر; Leishmania; Folate metabolism; Mitochondria; Drug target
Functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv: Purification and characterization
Keywords: هدف مواد مخدر; Mycobacterium tuberculosis; Shikimate pathway; Shikimate dehydrogenase; aroE; Enzyme kinetics; Protein purification; Drug target
Pro-apoptotic role of NF-κB: Implications for cancer therapy
Keywords: هدف مواد مخدر; NF-κB; Apoptosis; Cancer; Drug target
Cloning and characterization of angiotensin converting enzyme related dipeptidylcarboxypeptidase from Leishmania donovani
Keywords: هدف مواد مخدر; Kala-azar; Leishmania donovani; Dipeptidylcarboxypeptidase; Exopeptidases; Drug target
Casting light on molecular events underlying anti-cancer drug treatment: What can be seen from the proteomics point of view?
Keywords: هدف مواد مخدر; Drug development; Drug resistance; Drug target; Proteomics; 2-DE; Mass spectrometry; Anti-cancer compounds
Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception
Keywords: هدف مواد مخدر; MRG; mas-related gene; GPCR; G-protein-coupled receptor; GPCRs; Human-specific substitution; Darwinian positive selection; Drug target;
Engineered gene over-expression as a method of drug target identification
Keywords: هدف مواد مخدر; Dictyostelium; Osteoclast; Bone resorption; Drug target; Aminobisphosphonate; FDP synthase; Gene over-expression; Drug resistance;
The transcriptome's drugable frequenters
Keywords: هدف مواد مخدر; Drug Discovery; genomics; microarray; transcriptome; drug target; gene frequency;
Pharmacogenomics and cardiovascular drugs: Need for integrated biological system with phenotypes and proteomic markers
Keywords: هدف مواد مخدر; ABC transporter; Antiobesity drug; Cardiovascular disease; Cardiovascular drug; Drug-metabolizing enzyme; Drug target; Inflammation; Nutrigenetics; Nutrigenomics; Obesity; Pharmacodynamic; Pharmacogenetic; Statin;