کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10871348 1074051 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacological protein targets in polyglutamine diseases: Mutant polypeptides and their interactors
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Pharmacological protein targets in polyglutamine diseases: Mutant polypeptides and their interactors
چکیده انگلیسی
Polyglutamine diseases are a group of pathologies affecting different parts of the brain and causing dysfunction and atrophy of certain neural cell populations. These diseases stem from mutations in various cellular genes that result in the synthesis of proteins with extended polyglutamine tracts. In particular, this concerns huntingtin, ataxins, and androgen receptor. These mutant proteins can form oligomers, aggregates, and, finally, aggresomes with distinct functions and different degrees of cytotoxicity. In this review, we analyze the effects of different forms of polyQ proteins on other proteins and their functions, which are considered as targets for therapeutic intervention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 587, Issue 13, 27 June 2013, Pages 1997-2007
نویسندگان
, , , , ,