کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4371704 1302536 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasmodium falciparum: Growth response to potassium channel blocking compounds
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Plasmodium falciparum: Growth response to potassium channel blocking compounds
چکیده انگلیسی

Potassium channels are essential for cell survival and regulate the cell membrane potential and electrochemical gradient. During its lifecycle, Plasmodium falciparum parasites must rapidly adapt to dramatically variant ionic conditions within the mosquito mid-gut, the hepatocyte and red blood cell (RBC) cytosols, and the human circulatory system. To probe the participation of K+ channels in parasite viability, growth response assays were performed in which asexual stage P. falciparum parasites were cultured in the presence of various Ca2+-activated K+ channel blocking compounds. These data describe the novel anti-malarial effects of bicuculline methiodide and tubocurarine chloride and the novel lack of effect of apamine and verruculogen. Taken together, the data herein imply the presence of K+ channels, or other parasite-specific targets, in P. falciparum-infected RBCs that are sensitive to blockade with Ca2+-activated K+ channel blocking compounds.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 120, Issue 3, November 2008, Pages 280–285
نویسندگان
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