کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3461639 1231390 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cellular Sources of Extracellular Matrix in Hepatic Fibrosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Cellular Sources of Extracellular Matrix in Hepatic Fibrosis
چکیده انگلیسی

The deposition of increased and abnormal extracellular matrix is the hallmark of liver fibrosis. Hepatic stellate cells are well known as the major source of the fibrillar collagens and other components of the liver scar, but are now appreciated to be only one of many potentially fibrogenic cell populations in the diseased liver. Portal fibroblasts and circulating mesenchymal cells derived from the bone marrow are also important sources of matrix proteins in fibrosis. Recent data suggest that hepatocytes and biliary epithelial cells undergo an epithelial to mesenchymal transition, similarly assuming a fibrogenic phenotype. Sinusoidal endothelial cells and hepatocytes produce specific matrix proteins important in liver health and disease. The future challenge will be to define more explicitly the roles of these different fibrogenic cell populations in fibrosis in a disease-specific way.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinics in Liver Disease - Volume 12, Issue 4, November 2008, Pages 759–768
نویسندگان
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