کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3463378 1231553 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Random-effects model for meta-analysis of clinical trials: An update
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Random-effects model for meta-analysis of clinical trials: An update
چکیده انگلیسی

The random-effects model is often used for meta-analysis of clinical studies. The method explicitly accounts for the heterogeneity of studies through a statistical parameter representing the inter-study variation. We discuss several iterative and non-iterative alternative methods for estimating the inter-study variance and hence the overall population treatment effect. We show that the leading methods for estimating the inter-study variance are special cases of a general method-of-moments estimate of the inter-study variance. The general method suggests two new two-step methods. The iterative estimate is statistically optimal and it can be easily calculated on a spreadsheet program, such as Microsoft Excel, available on the desktop of most researchers. The two-step methods approximate the optimal iterative method better than the earlier one-step non-iterative methods.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contemporary Clinical Trials - Volume 28, Issue 2, February 2007, Pages 105–114
نویسندگان
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