کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3466375 1596560 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The genotype C could play a key role in hepatitis B virus associated nephritis among the Northwest Chinese children
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
The genotype C could play a key role in hepatitis B virus associated nephritis among the Northwest Chinese children
چکیده انگلیسی

BackgroundHepatitis B virus-associated glomerulonephritis (HBV-GN) is a kind of immune complex-induced glomerulonephritis. The present study was designed to determine whether Hepatitis B virus (HBV) genotype is associated with glomerulonephritis in north-west Chinese children.MethodsA total of 296 HBV-infected patients were enrolled in this study. The serum of patients was subjected to DNA extraction and the HBV genotypes were determined by PCR.ResultsThe results showed that genotype C (49%) was predominant within the subjects, compared to HBV/B (38.5%), B/C recombinant (7.4%) and none B/C (5.1%). The serum tests showed that the changes of Complement 3 (C3) and alanine amino transferase (ALT) levels in the genotype C patients were significantly greater than those in the genotype B patients. The frequency of genotype C in HBV-GN patients was higher than that in non HBV-GN patients (χ2 value = 30.239, P < 0.001). But, it was not associated with renal dysfunction. Furthermore, The genotype C was associated with high HBV-DNA load (82.9% vs 17.1%, P < 0.001), which is seen more frequently in the HBV-GN children (86.3% vs 13.3%, P = 0.004).ConclusionsThe genotype C may play a role in HBV-GN children, via favoring HBV replication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Internal Medicine - Volume 24, Issue 8, December 2013, Pages 835–838
نویسندگان
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