کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3467162 1596564 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evolving strategies for the use of spironolactone in cardiovascular disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Evolving strategies for the use of spironolactone in cardiovascular disease
چکیده انگلیسی

The evolution of strategies for the use of spironolactone and its analogue, eplerenone, has, over the years, encompassed favourable modification of the natural history of symptomatic heart failure in subjects with subnormal left ventricular ejection fraction (LVEF), and mitigation of the risk of new-onset atrial fibrillation in mildly symptomatic systolic heart failure. Given the fact that these benefits might be attributable, at least in part, to mitigation of severity of diastolic dysfunction when the latter co-exists with subnormal LVEF, what needs to be explored is the possibility of similar benefits from the use of these agents in patients such as those with hypertension, and aortic valve stenosis, in whom left ventricular dysfunction is of the predominantly diastolic subtype.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Internal Medicine - Volume 24, Issue 4, June 2013, Pages 303–309
نویسندگان
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