کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3467916 1596577 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Risk factors for pulmonary hypertension in patients with β thalassemia intermedia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Risk factors for pulmonary hypertension in patients with β thalassemia intermedia
چکیده انگلیسی

BackgroundPulmonary hypertension (PHT) is a common yet poorly understood complication of β thalassemia intermedia (TI).MethodsWe herein evaluated risk factors for PHT in TI, through comparing 64 TI patients with evidence of PHT by symptomatology and echocardiography (Group I) to age- and sex-matched TI patients without PHT (Group II). Retrieved data included demographics, laboratory parameters, clinical characteristics, and received treatments that may influence PHT development; and reflected the period prior to PHT occurrence in Group I.ResultsThe mean age of Group I patients at development of PHT was 37.3 ± 10.6 years; with 44% being males. Among studied parameters, Group I patients were more likely to be splenectomized (4.9-times), transfusion-naive (3.5-times); hydroxyurea-naive (2.6-times), or iron chelation-naive (2.3-times); and have nucleated red blood cell count ≥ 300 × 106/l (2.59-times) or a previous history of thromboembolic events (3.69-times).ConclusionTI patients who eventually develop PHT may be identified early on by being splenectomized, having high nucleated red blood cell counts and a previous history of thromboembolism. Prospective clinical trials that evaluate the efficacy, safety, and cost effectiveness of transfusion, iron chelation, and hydroxyurea therapy in preventing PHT in TI are invited.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Internal Medicine - Volume 22, Issue 6, December 2011, Pages 607–610
نویسندگان
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