کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3476100 1233240 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
All-trans retinoic acid-induced, life-threatening complete atrioventricular block
ترجمه فارسی عنوان
بلوک اتیرومتریکال کامل تهیه شده با اسید رتینوئیک، تهدید کننده زندگی است
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

We report a case of complete atrioventricular block (CAVB) with ventricular asystole and recurrent AVBs due to all-trans retinoic acid (ATRA). A 57-year-old man with acute promyelocytic leukemia was undergoing induction therapy with ATRA and developed episodic seizures with altered consciousness on the 14th day and then CAVB followed by cardiac arrest on the 15th day. Although he initially recovered after resuscitation, he suffered from recurrent CAVB, which persisted for 3 days despite immediate ATRA discontinuation. He then received ATRA retreatment with reduction of dosage, but a high-degree AVB recurred on the 5th day. After discontinuation of ATRA therapy, the patient recovered 3 days later without any cardiovascular event during follow-up. The serial electrocardiogram changes suggested an infra-Hisian block with possible ATRA dose-response relationship. To our knowledge, this is the first established case of ATRA-induced CAVB in the literature. We suggest clinical alertness for this life-threatening complication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Chinese Medical Association - Volume 78, Issue 5, May 2015, Pages 316–319
نویسندگان
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