A novel management of diabetes by means of strong antioxidants’ combination

Despite the current existence and availability of synthetic drugs for the treatment of diabetes mellitus (DM), these medications are neither cheap nor completely effective. Furthermore, the long-term consumption of synthetic drugs may cause adverse effects, while those medications provided from natural sources are more affordable and have shown lesser adverse effects. The current belief is that oxidative stress plays a substantial role in the pathogenesis of diabetes and its complications. The characteristics of DM as a multifactorial disease are related to a deficit in the β-cells of the pancreas that results in defective production and release of insulin. Antioxidant therapy can protect β-cells from apoptosis and preserve their function. Therefore, the higher the antioxidant effects a compound might have, the higher the positive effects in diabetes anticipated. Our idea is that a combination of strong antioxidants might positively work in control of hyperglycemia by activating the production and release of insulin to the blood. In this scenario, if the strongest multi-herbal antioxidant complex called Setarud (IMOD™) is combined with curcumin and quercetin, then much stronger antioxidant activity with positive effects in the control of diabetes would be produced. To prove the idea, this combination has to be pharmaceutically prepared and then its safety and efficacy must be examined in preclinical and clinical studies.

Schematic probable synergistic effects of combination Setarud, curcumin and quercetin in management of oxidative stress as main etiology of diabetes and its complication. Figure optionsDownload as PowerPoint slideHighlights▸ Diabetes is one of the most common health problems worldwide. ▸ Most current antidiabetic drugs have side effects and are costly. ▸ Oxidative stress plays a major role in the physiopathology of diabetes. ▸ Any herbal antidiabetic compound with higher antioxidative activity could be effective. ▸ We hypothesise the combination of Setarud with curcumin and quercetin for this purpose.