کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
35066 45071 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Angiotensin I-converting enzyme inhibitory peptides in red-mold rice made by Monascus purpureus
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Angiotensin I-converting enzyme inhibitory peptides in red-mold rice made by Monascus purpureus
چکیده انگلیسی

The ACE inhibitory activity in red-mold rice extracts, prepared from 24 strains of the genus Monascus, was measured. The most effective strain for ACE inhibition was Monascus purpureus IFO 4489 (IC50 = 0.71 mg/ml). Although the antihypertensive substance γ-amino butyric acid was detected in the red-mold rice (85.2 mg/kg), it did not contribute to ACE inhibition. Four ACE inhibitory peptides were isolated from the extract and identified as Ile-Tyr (IC50 = 4.0 μM), Val-Val-Tyr (22.0 μM), Val-Phe (49.7 μM) and Val-Trp (3.1 μM) by protein sequencing. The ACE inhibitory activity of these peptides was almost completely preserved after successive in vitro digestion by pepsin, chymotrypsin and trypsin. These results suggest that red-mold rice made by M. purpureus could be useful in alleviating hypertension.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Process Biochemistry - Volume 44, Issue 10, October 2009, Pages 1139–1143
نویسندگان
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