کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
35310 45086 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extraction of chlorpromazine with a new molecularly imprinted polymer from pig urine
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Extraction of chlorpromazine with a new molecularly imprinted polymer from pig urine
چکیده انگلیسی

Chlorpromazine is extensively used as a sedative hypnotic in veterinary application, however, improper and over usage of chlorpromazine pose a serious threat to human health and animal production. Due to the difficulty in monitoring trace level of chlorpromazine residues in complicated biological matrices, specific adsorption materials for preconcentration and clean-up of chlorpromazine are indispensable for sample preparation before further determination. In this study, a new molecularly imprinted polymer (MIP) for recognition of chlorpromazine was obtained by bulk polymerization. Then the imprinting effect of MIP was confirmed via chromatographic evaluation by compared with the corresponding non-imprinted polymer (NIP). Furthermore, the adsorption selectivity and capacity analysis revealed that the MIP had high specification for chlorpromazine. Finally, with the optimized protocol of molecularly imprinted solid-phase extraction (MISPE), the target analyte in pig urine at different spiked levels were selectively separated and purified for routine HPLC-UV analysis, with the improved recoveries above 73.3% and the intraday RSD of less than 8.7%, proving that the obtained MIP as specific SPE sorbents for extraction of chlorpromazine is applicable.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Process Biochemistry - Volume 43, Issue 11, November 2008, Pages 1209–1214
نویسندگان
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