کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
35427 | 45089 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A convenient preparation of dityrosine via Mn(III)-mediated oxidation of tyrosine
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
A simple method to rapidly and conveniently prepare dityrosine from l-tyrosine was developed using Mn(III) as an oxidizing agent. The best yield of the reaction was obtained from the 1 min equimolar reaction of l-tyrosine with Mn(III) acetate in 0.2 M sodium phosphate solution (pH 2.1) at 25 °C. Phosphate was removed by precipitation in ammonia water. The remaining tyrosine was mostly eliminated by precipitation in cold acidic water. Dityrosine was then further purified by HPLC, and its chemical structure was identified by NMR spectroscopy. Even though the yield was only 15.8%, this one-step Mn(III)-mediated oxidation of tyrosine allows dityrosine to be prepared without the need for complicated multi-step organic reactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Process Biochemistry - Volume 43, Issue 9, September 2008, Pages 999–1003
Journal: Process Biochemistry - Volume 43, Issue 9, September 2008, Pages 999–1003
نویسندگان
Dong-Ik Lee, Sangpill Hwang, Jee Yun Choi, Ik-Sung Ahn, Chang-Ha Lee,