کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
371706 621937 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Psychiatric illness in a cohort of adults with Prader-Willi syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Psychiatric illness in a cohort of adults with Prader-Willi syndrome
چکیده انگلیسی

Previous studies have suggested an association between PWS and comorbid psychiatric illness. Data on prevalence rates of psychopathology is still scarce. This paper describes a large-scale, systematic study investigating the prevalence of psychiatric illness in a Dutch adult PWS cohort. One hundred and two individuals were screened for psychiatric illness. Case vignettes were written by the first author on 63 individuals with a positive screening on psychopathology according to the interviews, medical history, medication use and behavioural questionnaires. These case vignettes were rated by two psychiatrists specializing in intellectual disability (ID). Psychopathology was divided into four diagnostic categories: bipolar disorder with psychotic symptoms, psychotic illness, depressive illness with psychotic symptoms and depressive illness without psychotic symptoms. Nine out of 53 persons (17%) with a 15q11–13 deletion and 28 out of 44 (64%) persons with maternal uniparental disomy (mUPD) were diagnosed with a current or previous psychiatric illness. Depressive illness with psychotic symptoms was the cause of psychiatric problems in the majority of persons with PWS due to deletion (56%). In the case of mUPD, almost all individuals with histories of psychopathology suffered from psychotic symptoms (85%) with or without affective component. Psychiatric examination should be part of general management of adults with PWS, especially when caused by mUPD. More attention should be paid to the presence of precursor symptoms, indicating a developing psychiatric episode. Longitudinal studies are needed to gain more insight into the natural history of psychiatric illness in adults with PWS.


► Psychiatric illness is highly prevalent in adults with PWS.
► 17% with a deletion and 64% with mUPD were diagnosed with a psychiatric illness.
► Depressive illness with psychotic symptoms was the most common cause in deletion.
► Psychotic symptoms ± affective component was the most common cause in mUPD.
► Psychiatric examination should be part of general management of adults with PWS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Developmental Disabilities - Volume 32, Issue 5, September–October 2011, Pages 1729–1735
نویسندگان
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