کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3801733 | 1244751 | 2012 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diagnóstico, tratamiento y seguimiento de la trombocitopenia inmune primaria
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کلمات کلیدی
Esplenectomia - اسپلنکتومیSplenectomy - اسپلنکتومی یا برداشتن طحال Inmunoglobulinas intravenosas - ایمونوگلوبولین های داخل وریدیIntravenous immunoglobulin - اﯾﻤﻮﻧﻮﮔﻠﻮﺑﻮﻟﯿﻦ ورﯾﺪیPrimary immune thrombocytopenia - ترومبوسیتوپنی اولیه ایمنیCorticosteroids - کورتیکواستروئیدهاGlucocorticoïdes - گلوکوکورتیکوئیدها
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The consensus document on the diagnosis, treatment and monitoring of primary immune thrombocytopenia was developed in 2010 by specialists with recognized expertise in this disease under the auspices of the Spanish Society of Hematology and Hemotherapy and the Spanish Society of Pediatric Hematology and Oncology, with the aim to adapt to Spain the recommendations of the recently published international consensus documents. The decision to start treatment is based on bleeding manifestations and platelet count (<Â 20Â ÃÂ 109/l). The first-line treatment is corticosteroids, albeit for a limited period of 4-6 weeks. The addition of intravenous immunoglobulin is reserved to patients with severe bleeding. Splenectomy is the most effective second-line treatment. For patients refractory to splenectomy and those with contraindications or patient refusal, the new thrombopoietic agents are the drugs of choice due to their efficacy and excellent safety profile. The other treatment options have highly variable response rates, and the absence of controlled studies does not allow to establish clear recommendations. Monitoring should be individualized. In patients without active treatment, blood counts are recommended every 3-6 months, and the patient should be instructed to consult in case of bleeding, surgery or invasive procedure and pregnancy. In most of the pediatric population, the disease tends to spontaneous remission. High-dose corticosteroids in short course and intravenous immunoglobulin are the treatment of choice. Second- and further-line treatments should be monitored in specialized centers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medicina ClÃnica - Volume 138, Issue 6, 17 March 2012, Pages 261.e1-261.e17
Journal: Medicina ClÃnica - Volume 138, Issue 6, 17 March 2012, Pages 261.e1-261.e17
نویسندگان
Miguel Ángel Sanz, Vicente Vicente GarcÃa, Antonio Fernández, M. Fernanda López, Carlos Grande, Isidro Jarque, Rafael MartÃnez, MarÃa Eva Mingot, Emilio Monteagudo, Josep Ma Ribera, David Valcárcel,