کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3804006 1244991 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Parkinson's disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Parkinson's disease
چکیده انگلیسی

Parkinson's disease (PD) is the second most common neurodegenerative condition affecting patients in the UK after Alzheimer's disease. It is broadly classified as a ‘movement disorder’ with a variety of clinical features, including bradykinesia, rigidity and tremor. Traditionally, focus has fallen on the treatment of ‘motor’ complications, such as tremor and mobility problems, although these features are only a small part of the clinical phenotype. In reality, PD is better defined as a multisystem neurodegenerative disorder causing a large number of motor and non-motor complications, and both aspects will be covered in this update. Although dopamine deficiency is the hallmark of the disease, other neurotransmitters involved in both motor and non-motor features of PD include acetylcholine, serotonin and noradrenaline. Diagnosis remains largely clinical and there are many potential pitfalls for the unwary clinician. Successful treatment relies heavily on a multidisciplinary approach with introduction of pharmacological therapy in a gradual, incremental and monitored setting. In the absence of definite disease-modifying agents, therapy remains symptomatic and complications increase as time progresses. Many of the most disabling complications are non-motor, and management of advanced PD is both complex and challenging. One of the most devastating non-motor consequences of PD is the development of Parkinson's disease dementia, which develops in up to 80% of subjects over time. The search for disease-modifying agents to both delay the onset of PD and reduce the burden of cognitive impairment is therefore of paramount importance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medicine - Volume 40, Issue 10, October 2012, Pages 529–535
نویسندگان
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