کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3804760 | 1245106 | 2014 | 5 صفحه PDF | دانلود رایگان |

Sjögren's syndrome is a systemic autoimmune disorder characterized by focal inflammation of the exocrine glands, leading to dry eyes and dry mouth. Two forms of the syndrome have been defined: primary (pSS), in which dysfunction of the exocrine glands occurs in the absence of other autoimmune diseases, and secondary (sSS), in which patients suffer additional autoimmune processes, especially connective tissue disorders such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and scleroderma. About 70% of patients with pSS have anti-Ro and/or anti-La autoantibodies. Hypergammaglobulinaemia is also common and a proportion of patients have systemic involvement. Better use of symptomatic therapies can make a big difference to patients and there is also current interest in whether anti-B cell therapy could be effective in treating pSS.
Journal: Medicine - Volume 42, Issue 3, March 2014, Pages 162–166