کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3807284 1245352 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Parkinson’s disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Parkinson’s disease
چکیده انگلیسی

Parkinson’s disease (PD) is the second most common neurodegenerative condition affecting patients in the UK after Alzheimer’s disease. It is broadly classified as a ‘movement disorder’ with a variety of clinical features, including bradykinesia, rigidity and tremor. Traditional focus has fallen on the treatment of ‘motor’ complications such as tremor and mobility problems although these features are only a small part of the clinical phenotype. In reality, PD is better defined as a multisystem neurodegenerative disorder causing a large number of motor and non-motor complications, and both aspects will be covered in this update. Diagnosis remains largely clinical and there are many potential pitfalls for the unwary clinician. Successful treatment relies heavily on a multidisciplinary approach with introduction of pharmacological therapy in a gradual, incremental and monitored setting. In the absence of disease-modifying agents, therapy remains symptomatic and complications increase as time progresses. Many of the most disabling complications are non-motor, and management of advanced PD is both complex and challenging.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medicine - Volume 36, Issue 12, December 2008, Pages 630–635
نویسندگان
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