کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3813417 1245937 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intérêt de la documentation biologique de la maladie métastatique cérébrale dans le cancer du sein : à propos d'un cas
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Intérêt de la documentation biologique de la maladie métastatique cérébrale dans le cancer du sein : à propos d'un cas
چکیده انگلیسی
Breast cancer, after lung cancer, is the second major cause of brain metastases. In breast cancer, the prognosis is closely linked to the molecular subtype of the primary tumor. Targeted therapies, with or without cytotoxic treatment, have significantly modified overall survival in these patients. We report, the case of a patient suffering from breast cancer with brain metastasis in whom the biological documentation of the metastatic disease permitted to tailor the systemic treatment. Analysis of the surgical specimen revealed an immunohistochemical HER2 positive staining, which was not found in the primary tumor and therefore warranted trastuzumab administration. Another interesting insight based on this case report was to underline the phenotypic heterogeneity of the metastatic disease and its potential dynamic course as illustrated by the dissociated response to trastuzumab on body TEP-TDM in this particular patient. This case report also highlights the new place of the neurosurgeon in brain metastases management, not only as a participant in local treatment but also as a physician who is in fact involved in the delineation of the global oncological strategy in these patients as well as medical oncologists and radiation oncologists.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochirurgie - Volume 61, Issue 4, August 2015, Pages 271-274
نویسندگان
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