کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3828706 | 1246998 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Terapia con inmunoglobulinas intravenosas: medición seriada mediante ELISA de anticuerpos antidesmogleÃna 1 y 3 en tres pacientes con pénfigo vulgar
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
Intravenous immunoglobulin therapy (IVIg) has been used in the treatment of autoimmune bullous diseases unresponsive to conventional therapy in recent years. The action mechanism, which is not well known, suggests a wide spectrum of immunoregulation. In the last five years, several studies on patients with unresponsive pemphigus vulgaris with a clinical and serological outcome after IVIg administration in 80%-90% of cases have been published. We report the case of 3 patients with pemphigus vulgaris in whom we measured autoantibody titers to desmoglein 3 and 1 during 8 months. In spite of the clinical improvement, no significant decrease in antibody concentration was observed. Therapy with IVIg, although it has clinical benefit, did not decrease antibody values in our patients and thus it mayneed to be combined with immuno suppressant that inhibit pathogen antibody production.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista ClÃnica Española - Volume 206, Issue 10, November 2006, Pages 499-503
Journal: Revista ClÃnica Española - Volume 206, Issue 10, November 2006, Pages 499-503
نویسندگان
R. Suárez-Fernándeza, I. Longoa, J.A. Avilésa, C. Buenoa, M. RodrÃguez-Mahoub, P. Lázaroa,