Dry Weight: Sine Qua Non of Adequate Dialysis

Attainment of dry weight remains a major clinical problem and challenge in current-day dialysis therapies. The vicious cycle of fluid overload and inadequate intradialytic fluid removal with hypotensive episodes, and subsequent poor clinical outcomes, is reinforced by excessive salt accumulation orally as well as during dialysis. Negligence in recognizing the importance of fluid status in dialysis prescriptions with shortened times has contributed to the prevalence of overhydration. The treatment of this problem is exacerbated by the lack of adequate methods to diagnose and manage it. The recent findings of improved fluid status and prognosis with salt restriction, individualized dialysate sodium concentrations, and prolonged hemodialysis times when necessary with well-tolerated fluid removal rates show the path to prolonging survival of dialysis populations. The ongoing development of techniques permitting accurate assessment of hydration status, including those based on bioimpedance analysis, will provide an efficient tool in these efforts.