Eplerenona en la disfunción cardiorrenal y bloqueo del sistema renina-angiotensina-aldosterona

Aldosterone produces retention of Na+ and water and loss of K+, as well as substantial independent effects on epithelia. The use of mineralocorticoid receptor blockers reduces the damage produced by aldosterone in patients with cardio-renal dysfunction. Eplerenone, a novel and specific antagonist of mineralocorticoid receptors, has been approved for the treatment of patients with left ventricular systolic dysfunction after myocardial infarction. In this brief review, we analyze the effects of aldosterone, mineralocorticoid receptor blockade, and the molecule eplerenone, as well as the actions of this drug at different levels and its adverse effects.