La proteína relacionada con la paratirina: un nuevo mediador en la nefropatía diabética

Moreover, we observed upregulation of PTHrP in the glomeruli of diabetic patients, providing the first evidence of the participation of this protein in human renal disease. Finally, macrophage infiltration in the diabetic kidney has renewed interest in this phenomenon and PTHrP has been shown to have proinflammatory/profibrogenic effects, favoring the inflammatory process associated with DN. These findings suggest the role of PTHrP as a new mediator in the renal changes associated with diabetes.