The Impact of Histological Reclassification during Pathology Re-Review-Evidence of a Will Rogers Effect in Bladder Cancer?

Pathological re-review of radical cystectomy specimens identified variant histology in a third of patients. These variants are associated with a high rate of locally advanced disease, which may impact the noted rates of cancer specific and overall survival. Thus, it is critical to be aware of re-review status when interpreting outcomes from historical data sets and stratifying risk.