Distinctive Changes in Histone H3K4 Modification Mediated via Kdm5a Expression in Spermatogonial Stem Cells of Cryptorchid Testes

Recent investigations revealed that not only genetic but also epigenetic regulation has a role in spermatogenesis. Kdm5a is likely involved in the transformation of gonocytes into spermatogonial stem cells by transcriptional regulation of specific genes via H3K4 histone modification. To our knowledge this is the first report of epigenetic analysis of germ cell differentiation during early spermatogenesis.