Predictors of Survival of Advanced Renal Cell Carcinoma: Long-Term Results From Southwest Oncology Group Trial S8949

Nephrectomy prolonged long-term overall survival in this updated analysis, supporting its role as standard therapy in patients with advanced renal cell carcinoma. A nephrectomy benefit was seen across all prespecified patient subsets. Early progressive disease and performance status were strong predictors of overall survival. These results support efforts to identify biomarkers of renal cell carcinoma resistance to treatment and early progressive disease to facilitate rational patient selection for systemic therapy.