کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3871327 1598983 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Clinical Significance in Healthy Men of the Association Between Obesity Related Plasma Hemodilution and Tumor Marker Concentration
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
The Clinical Significance in Healthy Men of the Association Between Obesity Related Plasma Hemodilution and Tumor Marker Concentration
چکیده انگلیسی

PurposeWe investigated the association between body mass index and the concentration of tumor markers including carcinoembryonic antigen, α-fetoprotein, the carbohydrate antigen 19-9 and prostate specific antigen, as well as the association between body mass index changes and tumor marker concentration changes in a population of healthy men.Materials and MethodsWe evaluated data on 8,776 men screened for tumor markers (carcinoembryonic antigen, α-fetoprotein, carbohydrate antigen 19-9 and prostate specific antigen) at least 3 times annually during an annual examination from 2001 to 2007. We assessed the tumor marker test findings for a trend in the age, alanine aminotransferase and creatinine adjusted tumor marker concentration by body mass index. We used multivariate regression analysis to determine whether a change in body mass index was associated with a tumor marker concentration change over time using calculated tumor markers, body mass index, creatinine and alanine aminotransferase concentration change per year.ResultsAfter adjusting for age, creatinine and alanine aminotransferase a higher body mass index was associated with lower prostate specific antigen (p for trend <0.001), carcinoembryonic antigen (p for trend <0.001) and carbohydrate antigen 19-9 (p for trend <0.001). On multivariate regression analysis each 1 kg/m2 of body mass index gain per year was associated with a −0.011 ng/ml change in prostate specific antigen concentration, a –0.030 ng/ml change in carcinoembryonic antigen concentration and a −0.192 IU/ml change in carbohydrate antigen 19-9 concentration per year.ConclusionsIn this cohort of healthy men hemodilution from increased plasma volume may be responsible for the observed decreased tumor marker concentration in men with a higher body mass index. In addition, an increase in body mass index may predict a lower tumor marker concentration in an individual.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Urology - Volume 181, Issue 2, February 2009, Pages 567–573
نویسندگان
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