KINETICS, BIODISTRIBUTION AND THERAPEUTIC EFFICACY OF HEXYLESTER 5-AMINOLEVULINATE INDUCED PHOTODYNAMIC THERAPY IN AN ORTHOTOPIC RAT BLADDER TUMOR MODEL

An optimal PDT effect was obtained with 8 mM hALA and a fluence of 20 J/cm2. While different hALA concentrations induce identical PpIX fluorescence intensities, the PDT outcome was considerably different. Thus, fluorescence does not necessarily predict the therapeutic efficacy of PDT.