کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3884543 1249480 2010 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The BK potassium channel in the vascular smooth muscle and kidney: α- and β-subunits
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
The BK potassium channel in the vascular smooth muscle and kidney: α- and β-subunits
چکیده انگلیسی

The large-conductance voltage and calcium-sensitive BK channel is important in many electrically active cells. Its unique sensitivity to both intracellular calcium levels and membrane potential makes it a key regulator of intracellular calcium, a critical second messenger in cells. The BK channel is expressed ubiquitously in the body and has particularly significant roles in the neuronal and smooth muscle cells. More recently, the importance of BK channel in the pathophysiology of hypertension has been demonstrated. In this review, we will focus on function, regulation, and clinical significance of the BK channel. We will also specifically concentrate on one of its β-subunits, β1, which is important in vascular and renal physiology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 78, Issue 10, 2 November 2010, Pages 963–974
نویسندگان
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