کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3888248 | 1249614 | 2005 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Characteristics of Chinese patients with Wegener's granulomatosis with anti-myeloperoxidase autoantibodies Characteristics of Chinese patients with Wegener's granulomatosis with anti-myeloperoxidase autoantibodies](/preview/png/3888248.png)
Characteristics of Chinese patients with Wegener's granulomatosis with anti-myeloperoxidase autoantibodies.BackgroundCytoplasmic antineutrophil cytoplasmic autoantibodies (cANCA)/proteinase-3(PR3)-ANCA was considered the serologic diagnostic marker for Wegener's granulomatosis (WG). However, Chinese patients with MPO-ANCA positive WG were frequently diagnosed. We now analyze the characteristics of patients with MPO-ANCA positive WG and investigate the difference between patients with MPO-ANCA and PR3-ANCA.MethodsPatients with WG were selected according to both Chapel Hill Consensus Conference definition and American College of Rheumatology (ACR) classification criteria in 500 Chinese patients with ANCA-associated systemic vasculitides. The clinical manifestions were compared between patients with MPO-ANCA and with PR3-ANCA.ResultsEight-nine patients fulfilled the diagnostic criteria of WG: 54/89(60.7%) were MPO-ANCA positive, 34/89(38.2%) were PR3-ANCA positive. Patients with MPO-ANCA were predominantly female compared with patients with PR3-ANCA. Patients with MPO-ANCA also had multisystem involvement. However, the prevalences of arthagia, skin rash, ophthalmic and ear involvement were significantly lower in patients with MPO-ANCA than those in patients with PR3-ANCA (46.3% vs. 70.6%, P < 0.05; 20.4% vs. 44.1%, P < 0.05; 27.8% vs. 58.8%, P < 0.01; 40.7% vs. 67.6%, P < 0.05, respectively). The prevalence of elevated initial serum creatinine was significantly higher in patients with MPO-ANCA than that in patients with PR3-ANCA (81.5% vs. 61.8%, χ2 = 4.20, P < 0.05).ConclusionPatients with MPO-ANCA positive WG were not rare in Chinese.
Journal: Kidney International - Volume 68, Issue 5, November 2005, Pages 2225–2229