کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3896944 1250236 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vasopressin and Aquaporin 2 in Clinical Disorders of Water Homeostasis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Vasopressin and Aquaporin 2 in Clinical Disorders of Water Homeostasis
چکیده انگلیسی

SummaryImpaired urinary dilution leading to water retention and hyponatremia may occur in patients with cardiac failure, cirrhosis, pregnancy, oxytocin administration, hypothyroidism, glucocorticoid, and mineralocorticoid deficiency. The mechanisms for these defects predominantly involve the nonosmotic stimulation of arginine vasopressin release with up-regulation of aquaporin 2 water channel expression and trafficking to the apical membrane of the principal cells of the collecting duct. These perturbations are reversed by V2 vasopressin receptor antagonists. In contrast, urinary concentration defects leading to polyuria are vasopressin resistant. They may involve several factors, such as impaired countercurrent concentration secondary to down-regulation of Na-K-2Cl cotransporter. Vasopressin-resistant down-regulation of aquaporin 2 expression has also been described as a factor in impaired urinary concentration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Nephrology - Volume 28, Issue 3, May 2008, Pages 289–296
نویسندگان
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