Asymmetric reactions of chiral organo-magnetic nanoparticles

• Chiral organocatalysts supported on magnetic nano particles (MNPs) have been divided into five categories and discussed their application towards asymmetric reactions.
• The structures of each catalyst, immobilization technique on MNPs, catalytic efficiency and number of reusable cycles have also been discussed as simple as possible for researchers.
• Smaller size and high surface area of pseudo-heterogeneous nature of these MNPs lead to excellent loading and high catalytic activity.
• Separation of the catalyst from a reaction mixture is very easy and simple by applying with an external magnet.

Magnetic nanoparticles (MNPs) have been widely used as a catalytic supports. MNPs have high surface-area that allows the design and setup of many catalytic sites. Their surfaces can be modified with chiral organocatalyst (COC) to become a sustainable catalytic material. This functionalized magnetite can be easily separated using an external magnet after reaction. We summarize the use of COC-MNPs which are robust and readily available for chiral transformation. The catalytic activity, recyclability, and immobilization method of COC-MNPs are described. The catalytic load, size of the particles, solvent system, ee values and de ratios are also evaluated on each asymmetric reaction.

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