کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3907264 | 1251030 | 2012 | 16 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Uses of cell free fetal DNA in maternal circulation Uses of cell free fetal DNA in maternal circulation](/preview/png/3907264.png)
For over a decade, researchers have focused their attention on the development of non-invasive prenatal diagnosis tests based on cell-free fetal DNA circulating in maternal blood. With the possibility of earlier and safer testing, non-invasive prenatal diagnosis has the potential to bring many positive benefits to prenatal diagnosis. Non-invasive prenatal diagnosis for fetal sex determination for women who are carriers of sex-linked conditions is now firmly established in clinical practice. Other non-invasive prenatal diagnosis-based tests are set to follow, as future applications, such as the detection of single-gene disorders and chromosomal abnormalities, are now well within reach. Here, we review recent developments in non-invasive prenatal diagnosis for genetic conditions and chromosomal abnormalities, and provide an overview of research into ethical concerns, social issues and stakeholder view points.
Journal: Best Practice & Research Clinical Obstetrics & Gynaecology - Volume 26, Issue 5, October 2012, Pages 639–654