کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3907505 1599309 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In utero stem cell transplantation and gene therapy: Recent progress and the potential for clinical application
ترجمه فارسی عنوان
پیوند سلول های بنیادی رحمی و ژن درمان: پیشرفت اخیر و پتانسیل کاربرد بالینی
کلمات کلیدی
درمان پیش از بارداری، ژن درمانی، پیوند سلول بنیادی خونریزی، در دوران جنینی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

Advances in prenatal diagnosis have led to the prenatal management and treatment of a variety of congenital diseases. Although surgical treatment has been successfully applied to specific anatomic defects that place the fetus at a risk of death or life-long disability, the indications for fetal surgical intervention have remained relatively limited. By contrast, prenatal stem cell and gene therapy await clinical application, but they have tremendous potential to treat a broad range of genetic disorders. If there are biological advantages unique to fetal development that favor fetal stem cell or gene therapy over postnatal treatment, prenatal therapy may become the preferred approach to the treatment of any disease that can be prenatally diagnosed and cured by stem cell or gene therapy. Here, we review the field including recent progress toward clinical application and imminent clinical trials for cellular and gene therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Obstetrics & Gynaecology - Volume 31, February 2016, Pages 88–98
نویسندگان
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