Influence of histology on the effectiveness of adjuvant chemotherapy in patients with hormone receptor positive invasive breast cancer

► Invasive lobular breast cancer (ILC) is less responsive to neoadjuvant chemotherapy than ductal cancer (IDC). ► Patients with ILC also seem to benefit less from adjuvant chemotherapy than patients with IDC. ► Further research, based on randomized data or larger patient series, is urgently needed.