کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3910248 1251249 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A data model to predict HER2 status in breast cancer based on the clinical and pathologic profiles of a large patient population at a single institution
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
A data model to predict HER2 status in breast cancer based on the clinical and pathologic profiles of a large patient population at a single institution
چکیده انگلیسی
Recently published clinical trial data have produced compelling evidence for increased survival when Herceptin is administered to patients whose tumors are HER2 amplified. Therefore, the accuracy of HER2 status is essential to determine which patients should or should not receive Herceptin. Although HER2 results obtained by FISH and IHC are often in agreement, there is a persistent group of cases in which results are discordant, particularly among tumors with intermediate results. A multivariable analysis was undertaken to determine relative significance of various clinical and pathologic findings for patients diagnosed with infiltrating ductal carcinoma, and a data model was produced that predicts which patients are most likely to have HER2 amplified tumors. Correlates of HER2 amplification were higher Scarff-Bloom-Richardson grade, younger age at diagnosis, and a comedo ductal carcinoma in situ component.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 15, Issue 6, December 2006, Pages 728-735
نویسندگان
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