کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3915547 1251513 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bone mineral density in women aged 25–35 years receiving depot medroxyprogesterone acetate: recovery following discontinuation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Bone mineral density in women aged 25–35 years receiving depot medroxyprogesterone acetate: recovery following discontinuation
چکیده انگلیسی

IntroductionThis 7-year, prospective, matched-cohort, clinical study evaluated the effects of intramuscular depot medroxyprogesterone acetate (DMPA) (150 mg/mL) on bone mineral density (BMD) in women aged 25–35 years.MethodsBone mineral density changes in new DMPA-IM users (n=248) were compared with those in women using nonhormonal contraception (n=360) for up to 240 weeks of treatment and 96 weeks of posttreatment follow-up (in subjects receiving ≥1 dose).ResultsAt week 240 of treatment, mean percentage changes from baseline in DMPA-IM vs. nonhormonal subjects were: −5.16% (n=21) vs. +0.19% (n=65), total hip (p<.001); −5.38% (n=33) vs. +0.43% (n=105), lumbar spine (p<.001). At week 96 posttreatment, these values were: −0.20% (n=25) vs. +0.84% (n=43), total hip (p=.047); −1.19% (n=41) vs. +0.47% (n=66), lumbar spine (p=.017).ConclusionsThese results show BMD declines during DMPA-IM use; following discontinuation, significant increases in BMD occur through 96 weeks posttreatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contraception - Volume 74, Issue 2, August 2006, Pages 90–99
نویسندگان
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