کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3916417 1599467 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Safety of histamine-2 receptor blockers in hospitalized VLBW infants
ترجمه فارسی عنوان
ایمنی مسدودکننده های گیرنده هیستامین -2 در نوزادان بیمارستانی VLBW
کلمات کلیدی
آنتاگونیست های گیرنده هیستامین 2؛ مسدودکننده H2؛ نوزادان؛ انتروكولیت نكروتیزی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی


• Using a multicenter electronic health record based clinical database, we characterized histamine-2 receptor (H2) blocker use in very low birth weight (VLBW) infants.
• We found that despite decreasing use over time, VLBW infants frequently remained exposed to H2 blockers and that exposure was associated with increased morbidity and mortality.

BackgroundHistamine-2 receptor (H2) blockers are often used in very low birth weight infants despite lack of population specific efficacy and safety data.AimsWe sought to describe safety and temporal trends in histamine-2 receptor (H2) blocker use in hospitalized very low birth weight (VLBW) infants.Study designWe conducted a retrospective cohort study using a clinical database populated by an electronic health record shared by 348 neonatal intensive care units in the United States.SubjectsWe included all VLBW infants without major congenital anomalies.Outcome measuresWe used multivariable logistic regression with generalizing estimating equations to evaluate the association between days of H2 blocker exposure and risk of: 1) death or necrotizing enterocolitis (NEC); 2) death or sepsis; and 3) death, NEC, or sepsis.ResultsOf 127,707 infants, 20,288 (16%) were exposed to H2 blockers for a total of 6,422,352 days. Median gestational age for infants exposed to H2 blockers was 27 weeks (25th 75th percentile 26, 29). H2 blocker use decreased from 18% of infants in 1997 to 8% in 2012 (p < 0.001). On multivariable analysis, infants were at increased risk of the combined outcome of death, NEC, or sepsis on days exposed to H2 blockers (odds ratio = 1.14) (95% confidence interval 1.08, 1.19).ConclusionsH2 blocker use is associated with increased risk of the combined outcome of death, NEC, or sepsis in hospitalized VLBW infants.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Early Human Development - Volume 99, August 2016, Pages 27–30
نویسندگان
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