کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3917891 1252153 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathophysiology of patent ductus arteriosus in premature neonates
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Pathophysiology of patent ductus arteriosus in premature neonates
چکیده انگلیسی

Failure of complete postnatal closure of the ductus arteriosus is associated with various neonatal morbidities. Functional closure resulting from smooth muscle constriction and permanent anatomic closure due to vascular remodeling are the results of a complex interaction of different mechanisms. Prostaglandins, oxygen, nitric oxide and various other factors play a key role in ductal closure. An understanding of the role of these factors, involved both in maintenance of vascular tone of the ductus in fetal life as well as stimulation of ductal closure in postnatal life, and the cardiovascular and respiratory consequences of a patent ductus arteriosus, is important for the clinician involved in management of premature neonates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Early Human Development - Volume 85, Issue 3, March 2009, Pages 143–146
نویسندگان
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