کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3920724 1599847 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased expression of alpha-enolase in cervico-vaginal fluid during labour
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Increased expression of alpha-enolase in cervico-vaginal fluid during labour
چکیده انگلیسی

ObjectivesThe aim of this study was (i) to characterise differentially expressed proteins in cervico-vaginal fluid (CVF) at the time of preterm labour onset and (ii) to confirm these studies in human CVF samples taken from women before and during spontaneous labour.Study designPreterm labour was induced in sheep (n = 5) via fetal dexamethasone infusion (1 mg/24 h). CVF samples were taken prior to dexamethasone infusion (0 h), 28 h after the start of dexamethasone infusion, and immediately prior to delivery. Two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) were used to identify differentially expressed proteins. For the human studies, paired CVF samples were taken 5–9 days before labour and during spontaneous labour onset (n = 7).ResultsThere was a 4.2-fold increase in α-enolase protein expression in sheep CVF during labour. Likewise, α-enolase protein expression was significantly increased during spontaneous human labour at term.ConclusionsAlpha-enolase is known to be bound to neutrophils and interact in the immune response, and thus may play a role in inflammation associated with human labour.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 153, Issue 1, November 2010, Pages 16–22
نویسندگان
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