کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3920766 1599849 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Absence of activating somatic mutations of PI3KCA and AKT1 genes in South Indian women with endometriosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Absence of activating somatic mutations of PI3KCA and AKT1 genes in South Indian women with endometriosis
چکیده انگلیسی

ObjectiveTo investigate whether the PI3KCA and AKT1 gene influences the risk of developing endometriosis in South Indian women.Study designMutations in exon 9 and 20 of PI3KCA gene and E17K mutation in exon 4 of AKT1 gene were tested for association in a case–control study between eutopic and ectopic endometrium tissue from 30 endometriosis cases and eutopic endometrium tissue from 30 controls. The genotype frequencies of these mutations were compared using polymerase chain reaction and direct sequencing analysis of tissue DNA.ResultsThe analysis did not reveal any activating somatic mutations in either PI3KCA or AKT1 gene in the cases.ConclusionIn the present study we could not observe any mutation in PI3KCA and AKT1 gene, indicating that these mutations are rarely associated with endometriosis in South Indian women.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 152, Issue 1, September 2010, Pages 78–82
نویسندگان
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