کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3921275 1599857 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Growth inhibition of human ovarian cancer cells by blocking STAT3 activation with small interfering RNA
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Growth inhibition of human ovarian cancer cells by blocking STAT3 activation with small interfering RNA
چکیده انگلیسی

ObjectiveSignal transducer and activator of transcription 3 (STAT3) are constitutively activated in a variety of cancers and it is a common feature of ovarian cancer. Thus, STAT3 represents a promising molecular target for tumor therapy. We applied a DNA vector-based STAT3-specific RNA interference approach which specifically blocks over-activated STAT3, to treat human ovarian cancer cells, and evaluated the cellular proliferation ability and investigated the molecular mechanisms in vitro.Study designA DNA vector-based RNA interference approach was used to knockdown STAT3 expression in human ovarian cancer cells in vitro.ResultsThe STAT3 siRNA down-regulated the expression of cyclin D1, survivin, and VEGF in ovarian cancer cells both at transcription and translation levels. Inhibition of STAT3 and its related genes was accompanied by growth suppression and induction of apoptosis in cancer cells in vitro.ConclusionsThese data indicate that STAT3 signaling is a promising molecular target for ovarian cancer therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 148, Issue 1, January 2010, Pages 73–80
نویسندگان
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