Patients’ obstetric history in mid-trimester termination of pregnancy with gemeprost: Does it really matter?

ObjectiveThe objective was to investigate the importance of previous obstetric history for termination of pregnancy in the second-trimester with gemeprost alone.Study designA consecutive series of 423 mid-trimester inductions of abortion at our teaching hospital was reviewed. Termination of pregnancy was carried out with 1 mg of vaginal gemeprost every 3 h up to three doses over a 24-h period, repeated the following day if necessary. Failed induction was defined as women undelivered by 96 h. The study population was then stratified by gestational age, parity, gravidity and previous uterine scars. Main outcome parameters were failed induction and complication rates. Statistical analysis was performed using the χ2 test or Fisher's exact test for categorical data, and the t-test and linear regression for continuous variables.ResultsNo significant differences were found in the primary outcome parameters with regard to the obstetric parameters considered. The failed induction rate was 1.2% with an overall incidence of complications of 7.4%. Parity was the main factor that affected clinical response (time to abortion interval and number of pessaries).ConclusionPatients’ obstetric history does affect the clinical response to gemeprost, but its safety and effectiveness are preserved. These data provide clinicians with important information for correct counselling.