کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3924222 1253097 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diagnostic Efficacy of [11C]Choline Positron Emission Tomography/Computed Tomography Compared With Conventional Computed Tomography in Lymph Node Staging of Patients With Bladder Cancer Prior to Radical Cystectomy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Diagnostic Efficacy of [11C]Choline Positron Emission Tomography/Computed Tomography Compared With Conventional Computed Tomography in Lymph Node Staging of Patients With Bladder Cancer Prior to Radical Cystectomy
چکیده انگلیسی

BackgroundCurrent imaging techniques are of limited value for lymph node (LN) staging in bladder cancer (BCa) patients scheduled for radical cystectomy (RC).ObjectiveEvaluate the diagnostic efficacy of [11C]choline positron emission tomography in combination with computed tomography (PET/CT) for LN staging of patients with BCa scheduled for RC and compare that efficacy with the diagnostic efficacy of CT and the gold standard of histopathologic evaluation.Design, setting, and participantsFrom June 2004 to May 2007, 44 patients with localized BCa were staged with [11C]choline PET with low-dose CT for attenuation correction and simultaneous intravenous and rectal contrast-enhanced diagnostic CT before RC and pelvic lymph node dissection (PLND). LNs were dissected from the internal and external iliac arteries up to the origin of the inferior mesentery artery according to a template with 14 predefined anatomic fields.InterventionDiagnostic [11C]choline PET/CT before RC and regional LN dissection.MeasurementsHistopathologic findings of resected LN were correlated with the results of [11C]choline PET/CT and CT alone in a patient- and field-based manner. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of [11C]choline PET/CT and CT were assessed.Results and limitationsLN metastases were found in 12 of 44 patients (27%). On patient-based analysis, sensitivity, specificity, PPV, NPV, and accuracy for [11C]choline PET/CT were calculated as 58%, 66%, 39%, 81%, and 64%, respectively; and for CT the calculated percentages were 75%, 56%, 39%, 86%, and 61%, respectively. Twenty-five of 471 dissected LN fields (5%) showed metastases. On field-based analysis, sensitivity, specificity, PPV, NPV, and accuracy for [11C]choline PET/CT were 28%, 95%, 21%, 96%, and 91%, respectively; for CT, the calculated percentages were 39%, 92%, 20%, 96%, and 90%, respectively. Limitations of this study are small patient number and the fact that not all patients underwent extensive PLND.ConclusionsIn patients with BCa who were scheduled for RC, preoperative LN staging with [11C]choline PET/CT was not able to improve diagnostic efficacy compared with conventional CT alone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Urology - Volume 61, Issue 5, May 2012, Pages 1031–1038
نویسندگان
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