کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3925232 1253124 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Loss and Progressive Recovery of Voiding after Spinal Cord Interruption in Rats is Associated with Simultaneous Changes in Autonomous Contractile Bladder Activity
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
The Loss and Progressive Recovery of Voiding after Spinal Cord Interruption in Rats is Associated with Simultaneous Changes in Autonomous Contractile Bladder Activity
چکیده انگلیسی

BackgroundAutonomous contractile activity (ACA) is a well-known phenomenon in isolated bladders from different species and seems to be important in the physiology of both normal and dysfunctional voiding.ObjectiveTo determine whether ACA is changed in bladders from paraplegic rats at different periods post–spinal cord injury (post-SCI).Design, setting, and participantsACA was studied in bladders (at least six per group) from normal and paraplegic female Wister rats at different times post-SCI (2 h, 24 h, 1 wk, and 3 wk). A group of normal rats was used as a control group. For measurements bladders were incubated in organ baths under standardised conditions.MeasurementsACA was measured as pressure change, which was defined as either a transient change or a spiked change according to its characteristics. The effects of intravesical volume load and muscarinic agonists were studied.Results and limitationsFollowing spinal cord injury (SCI) a clear evolution in ACA was observed. In bladders from SCI rats in the acute areflexive voiding phase (1 wk post-SCI), we observed decreased ACA associated with a highly increased compliance and a changed response to muscarinic agonists. ACA in bladders from SCI rats with renewed voiding reflexes (3 wk post-SCI) was increased, together with a moderately increased compliance and a (moderately) changed response to muscarinic agonists.ConclusionsFrom these observations it is apparent that SCI leads to alterations in the behaviour and muscarinic response of ACA in the isolated bladder. These changes in ACA may play an important role in the pathophysiology of overactive bladder disease (OAB), and interacting with changed ACA might be promising in the search for newer treatments for OAB.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Urology - Volume 56, Issue 1, July 2009, Pages 168–176
نویسندگان
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